A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta

Arch Pharm Res. 2008 May;31(5):666-70. doi: 10.1007/s12272-001-1210-9. Epub 2008 May 15.


A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC(50) of 14.95 microM, followed by ursolic acid (2, IC(50) = 15.83 microM). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC(50) values ranging from 20.42 to 76.45 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinidia*
  • Animals
  • Lipase / antagonists & inhibitors*
  • Lipase / chemistry
  • Pancreas / enzymology*
  • Plant Extracts / chemistry
  • Plant Roots
  • Swine
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology


  • 3-O-p-coumaroyl actinidic acid
  • Plant Extracts
  • Triterpenes
  • Lipase