Assessing the current role of platelet function testing

Clin Cardiol. 2008 Mar;31(3 Suppl 1):I10-6. doi: 10.1002/clc.20361.


In vitro platelet function tests are commonly applied in research and offer justification for using antiplatelet therapy. However, studies assessing the ability of standardized platelet function tests to predict patients' clinical response to aspirin or clopidogrel have generated contradictory results. At this time, there is no standardized definition for resistance to antiplatelet therapy, and the appropriate treatment of patients who are hyporesponsive to these agents is not known. Although such tests have a role in research, their place in guiding therapy remains to be established, and prospective trials are urgently needed. The ideal platelet function test for clinical practice would be rapid, easy-to-use, inexpensive, and reliable.

Publication types

  • Review

MeSH terms

  • Blood Platelets / drug effects*
  • Cost-Benefit Analysis
  • Drug Resistance*
  • Equipment Design
  • Humans
  • Patient Selection
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Function Tests* / economics
  • Platelet Function Tests* / instrumentation
  • Platelet Function Tests* / standards
  • Predictive Value of Tests
  • Reproducibility of Results
  • Treatment Outcome


  • Platelet Aggregation Inhibitors