Cytokinesis: the final stop for the chromosomal passengers

Biochem Soc Trans. 2008 Jun;36(Pt 3):367-70. doi: 10.1042/BST0360367.


The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned since then about the role of the CPC in the late stages of mitosis and cytokinesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actomyosin / metabolism
  • Animals
  • Chromosomes / metabolism*
  • Cytokinesis*
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Intermediate Filaments / metabolism
  • Spindle Apparatus / metabolism


  • Cytoskeletal Proteins
  • Actomyosin