An overview of the fission yeast septation initiation network (SIN)

Biochem Soc Trans. 2008 Jun;36(Pt 3):411-5. doi: 10.1042/BST0360411.


The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Division
  • Meiosis
  • Protein Transport
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / growth & development
  • Schizosaccharomyces / metabolism*
  • Schizosaccharomyces pombe Proteins / metabolism*


  • Schizosaccharomyces pombe Proteins