The fetal response to chronic placental insufficiency

Semin Perinatol. 2008 Jun;32(3):201-5. doi: 10.1053/j.semperi.2007.11.002.


Fetal growth restriction is most commonly caused by failure of the placenta to meet the increasing demands for oxygen and substrate of the developing fetus, resulting in common fetal compensatory responses. Understanding these responses is helpful in developing a management strategy that will optimize pregnancy outcome.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological
  • Blood Flow Velocity
  • Female
  • Fetal Growth Retardation / etiology*
  • Fetal Hypoxia / metabolism
  • Fetal Hypoxia / physiopathology
  • Fetus / metabolism
  • Fetus / physiology*
  • Humans
  • Placenta / blood supply*
  • Placental Insufficiency / physiopathology*
  • Pregnancy