Caveats of caveolin-1 in Cancer Progression

Cancer Lett. 2008 Sep 18;268(2):187-201. doi: 10.1016/j.canlet.2008.03.055. Epub 2008 May 14.

Abstract

Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Caveolin 1 / analysis
  • Caveolin 1 / physiology*
  • Cell Adhesion
  • Cell Survival
  • Disease Progression
  • Extracellular Matrix / physiology
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / etiology*
  • Neoplasms / mortality
  • Neovascularization, Pathologic / etiology
  • Prognosis

Substances

  • Caveolin 1