Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration

J Appl Physiol (1985). 2008 Aug;105(2):433-45. doi: 10.1152/japplphysiol.00010.2008. Epub 2008 May 15.

Abstract

The influence of severe passive heat stress and hypohydration (Hypo) on cardiorespiratory and cerebrovascular function is not known. We hypothesized that 1) heating-induced hypocapnia and peripheral redistribution of cardiac output (Q) would compromise blood flow velocity in the middle cerebral artery (MCAv) and cerebral oxygenation; 2) Hypo would exacerbate the hyperthermic-induced hypocapnia, further decreasing MCAv; and 3) heating would reduce MCAv-CO2 reactivity, thereby altering ventilation. Ten men, resting supine in a water-perfused suit, underwent progressive hyperthermia [0.5 degrees C increments in core (esophageal) temperature (TC) to +2 degrees C] while euhydrated (Euh) or Hypo by 1.5% body mass (attained previous evening). Time-control (i.e., non-heat stressed) data were obtained on six of these subjects. Cerebral oxygenation (near-infrared spectroscopy), MCAv, end-tidal carbon dioxide (PetCO2) and arterial blood pressure, Q (flow model), and brachial and carotid blood flows (CCA) were measured continuously each 0.5 degrees C change in TC. At each level, hypercapnia was achieved through 3-min administrations of 5% CO2, and hypocapnia was achieved with controlled hyperventilation. At baseline in Hypo, heart rate, MCAv and CCA were elevated (P<0.05 vs. Euh). MCAv-CO2 reactivity was unchanged in both groups at all TC levels. Independent of hydration, hyperthermic-induced hyperventilation caused a severe drop in PetCO2 (-8+/-1 mmHg/ degrees C), which was related to lower MCAv (-15+/-3%/ degrees C; R2=0.98; P<0.001). Elevations in Q were related to increases in brachial blood flow (R2=0.65; P<0.01) and reductions in MCAv (R2=0.70; P<0.01), reflecting peripheral distribution of Q. Cerebral oxygenation was maintained, presumably via enhanced O2-extraction or regional differences in cerebral perfusion.

MeSH terms

  • Adult
  • Body Temperature / physiology
  • Carbon Dioxide / pharmacology
  • Cerebrovascular Circulation / physiology*
  • Dehydration / physiopathology*
  • Esophagus / physiology
  • Fever / physiopathology*
  • Humans
  • Hyperventilation / physiopathology
  • Hypocapnia / metabolism
  • Laser-Doppler Flowmetry
  • Male
  • Middle Cerebral Artery / physiopathology
  • Oxygen Consumption / physiology
  • Pulmonary Gas Exchange / physiology
  • Regional Blood Flow / physiology
  • Skin / blood supply
  • Supine Position / physiology

Substances

  • Carbon Dioxide