Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana

Genes Dev. 2008 May 15;22(10):1331-6. doi: 10.1101/gad.463608.

Abstract

Although the size of an organism is a defining feature, little is known about the mechanisms that set the final size of organs and whole organisms. Here we describe Arabidopsis DA1, encoding a predicted ubiquitin receptor, which sets final seed and organ size by restricting the period of cell proliferation. The mutant protein encoded by the da1-1 allele has a negative activity toward DA1 and a DA1-related (DAR) protein, and overexpression of a da1-1 cDNA dramatically increases seed and organ size of wild-type plants, identifying this small gene family as important regulators of seed and organ size in plants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / physiology*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • DNA, Complementary / physiology
  • Enhancer Elements, Genetic
  • Flowers / genetics
  • Flowers / growth & development
  • Gene Expression Regulation, Plant
  • Genes, Plant / physiology
  • Germination / genetics
  • LIM Domain Proteins
  • Multigene Family / physiology
  • Organ Size / genetics*
  • Plants, Genetically Modified
  • Promoter Regions, Genetic
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Seeds / growth & development*

Substances

  • Arabidopsis Proteins
  • DA1 protein, Arabidopsis
  • DNA, Complementary
  • LIM Domain Proteins
  • Receptors, Cell Surface