Trimetazidine revisited: a comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine

Cardiovasc Ther. Summer 2008;26(2):147-65. doi: 10.1111/j.1527-3466.2008.00043.x.

Abstract

Trimetazidine (TMZ) is an effective and well-tolerated antianginal drug that possesses protective properties against ischemia-induced heart injury. Growing interest in metabolic modulation in recent years urged an up-to-date review of the literature on TMZ. This review consists of two major sections: (1) comprehensive and critical information about the pharmacological effects, mechanism of action, pharmacokinetics, side effects, and current usage of TMZ, and (2) developments in analytical techniques for the determination of the drug in raw material, pharmaceutical dosage forms, and biological samples.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants* / adverse effects
  • Antioxidants* / analysis
  • Antioxidants* / pharmacokinetics
  • Antioxidants* / therapeutic use
  • Cardiovascular Agents* / adverse effects
  • Cardiovascular Agents* / analysis
  • Cardiovascular Agents* / pharmacokinetics
  • Cardiovascular Agents* / therapeutic use
  • Chemistry Techniques, Analytical / methods*
  • Chromatography / methods
  • Coronary Circulation / drug effects
  • Coronary Vessels / drug effects
  • Coronary Vessels / physiopathology
  • Electrochemistry
  • Energy Metabolism / drug effects
  • Flow Injection Analysis
  • Heart Diseases / drug therapy*
  • Heart Diseases / metabolism
  • Heart Diseases / physiopathology
  • Humans
  • Ischemia / drug therapy*
  • Ischemia / metabolism
  • Ischemia / physiopathology
  • Luminescent Measurements
  • Myocardial Contraction / drug effects
  • Myocardium / metabolism
  • Reactive Oxygen Species / metabolism
  • Spectrophotometry
  • Trimetazidine* / adverse effects
  • Trimetazidine* / analysis
  • Trimetazidine* / pharmacokinetics
  • Trimetazidine* / therapeutic use

Substances

  • Antioxidants
  • Cardiovascular Agents
  • Reactive Oxygen Species
  • Trimetazidine