Pseudoaneurysm of the peroneal artery: presentation of Ehlers-Danlos syndrome type IV

Eur J Vasc Endovasc Surg. 2008 Sep;36(3):353-5. doi: 10.1016/j.ejvs.2008.02.011. Epub 2008 May 15.


Introduction: Pseudoaneurysms in deep or unusual sites raise the possibility of an underlying vessel wall disorder.

Report: A 28-year-old woman presented with pain and swelling of her calf, with no history of trauma. Angiography diagnosed a peroneal artery pseudoaneurysm, which we embolised successfully. Subsequent genetic analysis revealed the COL3A1 mutation, confirming Ehlers-Danlos syndrome type IV.

Conclusion: To our knowledge, this is the first report of a peroneal artery pseudoaneurysm associated with underlying collagen vascular disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aneurysm, False / etiology*
  • Aneurysm, False / therapy
  • Collagen Type III / genetics
  • Ehlers-Danlos Syndrome / complications*
  • Ehlers-Danlos Syndrome / genetics
  • Embolization, Therapeutic
  • Female
  • Humans


  • COL3A1 protein, human
  • Collagen Type III