DeTEKting ubiquitination of APC/C substrates

Cell. 2008 May 16;133(4):570-2. doi: 10.1016/j.cell.2008.04.034.


Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals.

Publication types

  • Comment

MeSH terms

  • Amino Acid Motifs
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Humans
  • Proteins / chemistry
  • Proteins / metabolism*
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / chemistry
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitination


  • Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome