Abstract
Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoviridae Infections / virology*
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Animals
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Antigens, Viral / genetics
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Aviadenovirus / physiology*
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Capsid Proteins / genetics
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Cell Line, Tumor
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Coxsackie and Adenovirus Receptor-Like Membrane Protein
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Genetic Vectors / physiology*
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Humans
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Integrin alphaV / metabolism
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Oligopeptides / physiology*
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Reassortant Viruses / physiology*
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Receptors, Virus / deficiency
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Recombination, Genetic
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Transduction, Genetic
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Virus Replication
Substances
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Antigens, Viral
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CLMP protein, human
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Capsid Proteins
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Coxsackie and Adenovirus Receptor-Like Membrane Protein
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Integrin alphaV
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Oligopeptides
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Receptors, Virus
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hexon capsid protein, Adenovirus
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arginyl-glycyl-aspartic acid