The treatment of 126 patients with male sterility was analyzed. The low efficiency of therapy with hormonal and nonhormonal drugs in patients with testicular form of sterility was observed. The same patients clinically underwent general (intravenous) ozonotherapy. After one course (10 intravenous injections) stable positive clinicolaboratorial effect (increase of sperm density and qualitative characteristics of gametes) was detected in 28% patients. After 2-3 courses (with intervals of 3 months) positive dynamics was observed in almost 70% cases. Thus, general ozonotherapy should be considered as one of effective technologies of treatment in patients with male sterility.