Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 3 (1), 1-8

Role of Androgens, Progestins and Tibolone in the Treatment of Menopausal Symptoms: A Review of the Clinical Evidence

Affiliations
Review

Role of Androgens, Progestins and Tibolone in the Treatment of Menopausal Symptoms: A Review of the Clinical Evidence

Maria Garefalakis et al. Clin Interv Aging.

Abstract

Estrogen-containing hormone therapy (HT) is the most widely prescribed and well-established treatment for menopausal symptoms. High quality evidence confirms that estrogen effectively treats hot flushes, night sweats and vaginal dryness. Progestins are combined with estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot flushes, but are less effective than estrogen for this purpose. Data are conflicting regarding the role of androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot flushes and vaginal dryness. Tibolone may improve libido more effectively than estrogen containing HT in some women. We summarize the data from studies addressing the efficacy, benefits, and risks of androgens, progestins and tibolone in the treatment of menopausal symptoms.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

References

    1. Albertazzi P, Di Micco R, Zanardi E. Tibolone: a review. Maturitas. 1998;30:295–305. - PubMed
    1. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women’s Health Initiative randomized controlled trial. JAMA. 2004;291:1701–12. - PubMed
    1. Andrews H, Christie B, Colledge N, et al. Consensus Statement. J R Coll Physicians Edinb. 2004;34(suppl 13):2–3.
    1. Antoine C, Liebens F, Carly B, et al. Safety of alternative treatments for menopausal symptoms after breast cancer: a qualitative systematic review. Climacteric. 2007;10:23–6. - PubMed
    1. Antunes CMF, Stolley PD, Rosenstein MB. Endometrial cancer and estrogen use: report of a large case control study. N Engl J Med. 1979;300:9–13. - PubMed

Publication types

MeSH terms

Feedback