Long-term functional and anatomical results of osteo- and osteoodonto-keratoprosthesis

Graefes Arch Clin Exp Ophthalmol. 2008 Aug;246(8):1133-7. doi: 10.1007/s00417-008-0850-3. Epub 2008 May 20.


Purpose: To analyse the functional and anatomical results of keratoprosthesis using tooth and tibial autograft.

Methods: We reviewed 227 charts of patients that underwent osteo-keratoprosthesis (OKP) (n = 82) or osteo-odonto-keratoprosthesis (OOKP) (n = 145) at the Centro de Oftalmología Barraquer. Mean follow-up time was 8.4 years for OOKP and 3.5 years for OKP. Kaplan-Meier survival curves with 95% confidence interval (CI) were calculated for functional success, defined as BCVA >0.05. Anatomical success was defined as retention of the keratoprosthesis lamina. Visual Acuity by Time (VAT) Index with 95% CI was calculated for up to 2 years post-OKP and up to 6 years post-OOKP. Maximum visual acuity ever reached after the last step of the implantation of the keratoprosthesis was used as an indicator for the potential of the retina.

Results: Based on Kaplan-Meier analyses, 10-year anatomical survival was 66% (CI 57-76) for OOKP and 47% (CI 27-67) for OKP. Two-year functional survival was 63% (CI 55-71) for OOKP and 49% (CI 37-60) for OKP, and 10-year functional survival was 38% (CI 29-48) for OOKP and 17% (CI 5-28) for OKP. Multivariate analysis showed that neither surgical technique (OOKP or OKP), primary diagnosis nor age had a significant influence on the functional survival. However, a high maximum visual acuity ever reached post-op decreased the risk for functional failure. According to the VAT Index calculations, mean BCVA 2 years after OOKP was 0.33 (CI 0.28-0.41) and after OKP was 0.28 (CI 0.20-0.36).

Conclusion: Although we found a tendency that OOKP had better anatomical results than OKP, this difference was not statistically significant up to 10 years post-op. Functional results for both techniques were not significantly different at the 2-year follow-up, but at 10 years they were. However, this difference was influenced by the retinal potential and not by the technique itself.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Corneal Diseases / physiopathology
  • Corneal Diseases / surgery*
  • Female
  • Follow-Up Studies
  • Graft Survival / physiology
  • Humans
  • Male
  • Middle Aged
  • Ophthalmologic Surgical Procedures
  • Prosthesis Implantation
  • Retrospective Studies
  • Tibia / transplantation*
  • Tooth Root / transplantation*
  • Transplantation, Autologous
  • Visual Acuity / physiology*