A role for Numb in p53 stabilization

Genome Biol. 2008;9(5):221. doi: 10.1186/gb-2008-9-5-221. Epub 2008 May 9.

Abstract

The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism
  • Drosophila Proteins / metabolism
  • Humans
  • Juvenile Hormones / metabolism
  • Membrane Proteins / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Drosophila Proteins
  • Juvenile Hormones
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Numb protein, human
  • Tumor Suppressor Protein p53
  • numb protein, Drosophila