Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes

Reprod Biomed Online. 2008 May;16(5):608-10. doi: 10.1016/s1472-6483(10)60471-3.


Cryopreservation of oocytes by vitrification is a promising new technique for assisted human reproduction. Any new technical development must be accompanied with data concerning obstetric and perinatal outcome. This study analysed the obstetric and perinatal outcomes in 165 pregnancies and 200 infants conceived following oocyte vitrification cycles in three assisted reproduction centres. The results indicate that the mean birth weight and the incidence of congenital anomalies are comparable to that of spontaneous conceptions in fertile women or infertile women undergoing in-vitro fertilization treatment. These preliminary findings may provide reassuring evidence that pregnancies and infants conceived following oocyte vitrification are not associated with increased risk of adverse obstetric and perinatal outcomes.

MeSH terms

  • Adult
  • Birth Weight
  • Congenital Abnormalities
  • Female
  • Fertilization in Vitro / methods*
  • Humans
  • Infant, Newborn
  • Oocytes*
  • Pregnancy
  • Pregnancy Outcome*