Corrosive effect of nifedipine in the upper gastrointestinal tract

Diagn Ther Endosc. 1999;6(1):39-41. doi: 10.1155/DTE.6.39.


Upper gastrointestinal tract mucosa is prone to injury. Drugs may disturb gastric mucosa protective mechanisms and cause damage. Injury by NSAIDs is a well described complication. Nifedipine, a widely used drug, was not described before as having a potential to damage gastrointestinal mucosa. We describe here, two patients, who developed esophageal and gastric mucosal damage, probably related to Nifedipine ingestion.