Continuous muscle fiber activity, peripheral neuropathy, and thymoma

Ann Neurol. 1991 Feb;29(2):215-8. doi: 10.1002/ana.410290218.


Two patients, one of them with myasthenia gravis, presented symptoms of continuous muscle fiber activity syndrome before discovery of a thymoma. Peripheral neuropathy was present in both patients, with axonal and demyelinating lesions in sural nerve biopsy. The syndrome remained unchanged or worse after thymectomy. Both patients died of associated complications.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis / complications*
  • Peripheral Nervous System Diseases / complications*
  • Peripheral Nervous System Diseases / physiopathology
  • Thymectomy
  • Thymoma / complications*
  • Thymoma / surgery
  • Thymus Neoplasms / complications*
  • Thymus Neoplasms / surgery