Molecular structure of the Japanese hepatitis C viral genome

FEBS Lett. 1991 Mar 25;280(2):325-8. doi: 10.1016/0014-5793(91)80322-t.

Abstract

The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528) indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase, NTPase and RNA-dependent RNA polymerase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chymotrypsin / chemistry
  • Chymotrypsin / genetics
  • Flavivirus / genetics
  • Hepacivirus / genetics*
  • Molecular Sequence Data
  • Nucleoside-Triphosphatase
  • Pestivirus / genetics
  • Phosphoric Monoester Hydrolases / chemistry
  • Phosphoric Monoester Hydrolases / genetics
  • RNA-Dependent RNA Polymerase / chemistry
  • RNA-Dependent RNA Polymerase / genetics
  • Sequence Homology, Nucleic Acid
  • Solubility
  • Viral Proteins / chemistry
  • Viral Proteins / genetics*

Substances

  • Viral Proteins
  • RNA-Dependent RNA Polymerase
  • Phosphoric Monoester Hydrolases
  • Chymotrypsin
  • Nucleoside-Triphosphatase