Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases

Minerva Stomatol. 2008 May;57(5):227-32.


Aim: The present study examined retrospectively the clinical and radiographic characteristics of pyogenic granuloma (PG), peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF), located in the gingiva and alveolar ridge.

Methods: Biopsy records of the Stomatology Service of São Lucas Hospital-PUCRS were reviewed between 1980 and 2006. The medical charts of patients with histopathologic diagnosis of PG, PGCG and POF were selected. The data obtained were evaluated by means of descriptive statistics, analysis of variance (ANOVA), and the chi-squared test (chi-squared), considering the 5% level of significance.

Results: Of the 138 cases analyzed, 57.2% corresponded to PG, 22.5% to PGCG and 20.3% to POF. PG and POF exhibited a predilection for females and PGCG for males. PG occurred in younger individuals and showed a greater tendency for bleeding (P=0.018). PG showed a greater frequency of reddish color (P<0.001), PGCG purplish (P<0.001) and POF pinkish (P<0.001). In the radiographic examination, the presence of radiopaque foci was greater in POF (P<0.001), and resorption of the subjacent alveolar bone was found more often in PGCG (P<0.001). POF exhibited a longer evolution. There was no difference in lesions with respect to local irritating factors, ulceration, size, site and recurrence. Pregnancy was a factor linked to PG.

Conclusion: Despite the lesions investigated exhibit similar clinical characteristics, the present study demonstrated that aspects such as age of the patient and evolution, color, bleeding and radiographic characteristics can help in the differential diagnosis of these lesions.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Color
  • Female
  • Fibroma, Ossifying / diagnostic imaging
  • Fibroma, Ossifying / epidemiology*
  • Fibroma, Ossifying / pathology
  • Gingival Diseases / diagnostic imaging
  • Gingival Diseases / epidemiology*
  • Gingival Diseases / pathology
  • Gingival Hemorrhage / epidemiology
  • Gingival Hemorrhage / etiology
  • Gingival Neoplasms / diagnostic imaging
  • Gingival Neoplasms / epidemiology
  • Gingival Neoplasms / pathology
  • Granuloma, Giant Cell / diagnostic imaging
  • Granuloma, Giant Cell / epidemiology*
  • Granuloma, Giant Cell / pathology
  • Granuloma, Pyogenic / diagnostic imaging
  • Granuloma, Pyogenic / epidemiology*
  • Granuloma, Pyogenic / pathology
  • Humans
  • Jaw Diseases / diagnostic imaging
  • Jaw Diseases / epidemiology*
  • Jaw Diseases / pathology
  • Jaw Neoplasms / diagnostic imaging
  • Jaw Neoplasms / epidemiology
  • Jaw Neoplasms / pathology
  • Male
  • Middle Aged
  • Oral Ulcer / epidemiology
  • Oral Ulcer / etiology
  • Pregnancy
  • Pregnancy Complications / diagnostic imaging
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / pathology
  • Radiography
  • Retrospective Studies
  • Risk Factors
  • Sex Factors