A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab

Rheumatol Int. 2008 Sep;28(11):1155-9. doi: 10.1007/s00296-008-0590-z. Epub 2008 May 22.

Abstract

We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloidosis / drug therapy*
  • Amyloidosis / etiology*
  • Amyloidosis / pathology
  • Antibodies, Monoclonal / therapeutic use*
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / drug therapy*
  • Female
  • Humans
  • Infliximab
  • Middle Aged
  • Nephrotic Syndrome / drug therapy
  • Nephrotic Syndrome / etiology
  • Nephrotic Syndrome / pathology
  • Serum Amyloid A Protein
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Antibodies, Monoclonal
  • Serum Amyloid A Protein
  • Tumor Necrosis Factor-alpha
  • Infliximab