Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines

Cancer Biol Ther. 2008 Jun;7(6):842-4. doi: 10.4161/cbt.7.6.6298. Epub 2008 May 14.
No abstract available

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Apoptosis*
  • Cell Cycle
  • Cell Line, Tumor
  • Crk-Associated Substrate Protein / biosynthesis
  • Cyclin-Dependent Kinases / biosynthesis
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / physiology*
  • E2F1 Transcription Factor / biosynthesis
  • Humans
  • Models, Biological
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / physiology*
  • Phosphorylation
  • Protein Phosphatase 2 / biosynthesis
  • RNA-Binding Proteins / biosynthesis*
  • RNA-Binding Proteins / physiology*
  • Retinoblastoma Protein / biosynthesis*

Substances

  • BCAR1 protein, human
  • Crk-Associated Substrate Protein
  • DNA-Binding Proteins
  • E2F1 Transcription Factor
  • Nuclear Proteins
  • PPP1R10 protein, human
  • RNA-Binding Proteins
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases
  • Protein Phosphatase 2