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. 2008 Aug;16(8):1875-80.
doi: 10.1038/oby.2008.274. Epub 2008 May 22.

Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study

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Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study

Ka He et al. Obesity (Silver Spring). .
Free PMC article


Animal studies indicate that monosodium glutamate (MSG) can induce hypothalamic lesions and leptin resistance, possibly influencing energy balance, leading to overweight. This study examines the association between MSG intake and overweight in humans. We conducted a cross-sectional study involving 752 healthy Chinese (48.7% women), aged 40-59 years, randomly sampled from three rural villages in north and south China. The great majority of participants prepared their foods at home, without use of commercially processed foods. Diet was assessed with four in-depth multipass 24-h recalls. Participants were asked to demonstrate MSG amounts added in food preparation. Amounts shaken out were weighed by trained interviewers. Overweight was defined as BMI > or =25.0 or > or =23.0 kg/m(2)(based on World Health Organization recommendations for Asian populations). Eighty-two percent of participants were MSG users. Average intake was 0.33 g/day (s.d. = 0.40). With adjustment for potential confounders including physical activity and total energy intake, MSG intake was positively related to BMI. Prevalence of overweight was significantly higher in MSG users than nonusers. For users in the highest tertile of MSG intake compared to nonusers, the multivariable-adjusted odds ratios of overweight (BMI > or =23.0 and > or =25.0) were 2.10 (95% confidence interval, 1.13-3.90, P for trend across four MSG categories = 0.03) and 2.75 (95% confidence interval, 1.28-5.95, P = 0.04). This research provides data that MSG intake may be associated with increased risk of overweight independent of physical activity and total energy intake in humans.


Odds ratio of overweight (BMI ≥ 23.0 kg/m2) by gender according to MSG intake. adjustment for age, gender, and sample, smoking status, heavy activity, moderate activity, total energy intake, 24-hour excretion of sodium, and intakes (expressed as caloric density) of animal protein, saturated fat, monounsaturated fat, carbohydrates and fiber.

Comment in

  • Evidence that MSG does not induce obesity.
    Ebert AG. Ebert AG. Obesity (Silver Spring). 2009 Apr;17(4):629-30; author reply 630-1. doi: 10.1038/oby.2008.631. Obesity (Silver Spring). 2009. PMID: 19322148 No abstract available.

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