Herpes simplex vegetans: atypical genital herpes infection with prominent plasma cell infiltration in B-cell chronic lymphocytic leukemia

J Dtsch Dermatol Ges. 2008 Oct;6(10):865-7. doi: 10.1111/j.1610-0387.2008.06736.x. Epub 2008 May 21.
[Article in English, German]


Herpes simplex vegetans is a rare disorder even in immunocompromised patients. It typically affects patients with HIV or myeloproliferative diseases.The atypical cutaneous lesions show papillomatous vegetations in varying locations. Histologically the lesions show pseudoepitheliomatous hyperplasia of squamous epithelium, plasma cell infiltration and are positive for HSV 1 and/or HSV 2. Herpes simplex vegetans often responds poorly to treatment in immunocom-promised patients.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Herpes Genitalis / diagnosis*
  • Humans
  • Leukemia, B-Cell / diagnosis*
  • Male
  • Rectal Diseases / diagnosis*