In the past few years, the hair follicle has started revealing its beauty and mysteries. The existence of a growth and regeneration cycle, together with a unique tissue organization and complex regulatory network, make it a true paradigm of tissue homeostasis and dermal-epithelial crosstalk. In this brief review, I will describe some of the most recent results obtained in this very active research field of hair biology, underlining the diversity of the molecular signals that control hair growth and pigmentation.