Anti-angiogenic, antinociceptive and anti-inflammatory activities of Lonicera japonica extract

J Pharm Pharmacol. 2008 Jun;60(6):779-86. doi: 10.1211/jpp.60.6.0014.

Abstract

This study aimed to elucidate some novel pharmacological activities of Lonicera japonica (Caprifoliaceae), which is widely used in Oriental folk medicine. The ethanolic extract of L. japonica (LJ) dose dependently inhibited chick chorioallantoic membrane angiogenesis. The antinociceptive activity of LJ was assessed using the acetic acid-induced constriction model in mice. LJ showed anti-inflammatory activity in two in-vivo models: the vascular permeability and air pouch models. LJ suppressed the production of nitric oxide via down-regulation of inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW264.7 macrophage cells. However, LJ was unable to suppress induction of cyclooxygenase-2 in the stimulated macrophage cells. LJ decreased the reactive oxygen species level in the stimulated macrophage cells. In brief, the flowers of L. japonica possess potent anti-angiogenic and antinociceptive activities, in addition to anti-inflammatory activity, which partly supports its therapeutic efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / isolation & purification
  • Analgesics / pharmacology*
  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / isolation & purification
  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Chick Embryo
  • Chorioallantoic Membrane / drug effects
  • Chorioallantoic Membrane / metabolism
  • Cyclooxygenase 2 / drug effects
  • Cyclooxygenase 2 / metabolism
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Lonicera / chemistry*
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Male
  • Medicine, East Asian Traditional
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts / administration & dosage
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Reactive Oxygen Species / metabolism

Substances

  • Analgesics
  • Angiogenesis Inhibitors
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Reactive Oxygen Species
  • Cyclooxygenase 2