Case series analysis for censored, perturbed, or curtailed post-event exposures

Biostatistics. 2009 Jan;10(1):3-16. doi: 10.1093/biostatistics/kxn013. Epub 2008 May 21.

Abstract

A new method is developed for analyzing case series data in situations where occurrence of the event censors, curtails, or otherwise affects post-event exposures. Unbiased estimating equations derived from the self-controlled case series model are adapted to allow for exposures whose occurrence or observation is influenced by the event. The method applies to transient point exposures and rare nonrecurrent events. Asymptotic efficiency is studied in some special cases. A computational scheme based on a pseudo-likelihood is proposed to make the computations feasible in complex models. Simulations, a validation study, and 2 applications are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Biometry / methods
  • Clinical Trials as Topic / methods*
  • Clinical Trials as Topic / statistics & numerical data
  • Humans
  • Incidence
  • Life Tables*
  • Likelihood Functions
  • Models, Statistical*
  • Research Design / statistics & numerical data
  • Risk Assessment / methods
  • Time Factors