Acute pseudogout after pamidronate infusion

Clin Rheumatol. 2008 Sep;27(9):1205-6. doi: 10.1007/s10067-008-0923-z. Epub 2008 May 24.


A 72-year-old man, treated with a 60-mg intravenous infusion of pamidronate for shoulder hand syndrome, developed after few hours an acute pseudogout arthritis of his right knee. Diagnosis was confirmed by synovial fluid analysis and was associated with hypocalcemia. Only a few cases are reported in the literature. The mechanism of this potential side effect remains speculative.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Chondrocalcinosis / chemically induced*
  • Diphosphonates / administration & dosage
  • Diphosphonates / adverse effects*
  • Humans
  • Infusions, Intravenous
  • Male
  • Pamidronate
  • Reflex Sympathetic Dystrophy / drug therapy


  • Diphosphonates
  • Pamidronate