Endothelial signalling by Ig-like cell adhesion molecules

Transfus Clin Biol. Feb-Mar 2008;15(1-2):3-6. doi: 10.1016/j.tracli.2008.04.002. Epub 2008 May 23.


Leukocyte transendothelial migration is controlled by chemokine-induced signalling in leukocytes and integrin-ligand-induced bidirectional signalling in both leukocytes and endothelial cells. It is now generally accepted that endothelial signalling following leukocyte adhesion, serves to facilitate the crossing of the endothelium, be it via the paracellular or transcellular route. This brief overview discusses the main findings within this area and highlights some recent findings that shed new light on adhesion-induced signalling in the context of leukocyte transendothelial migration.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Endothelium, Vascular / physiology*
  • Humans
  • Immunoglobulins / physiology
  • Intercellular Adhesion Molecule-1 / physiology*
  • Leukocytes / physiology*
  • Platelet Endothelial Cell Adhesion Molecule-1 / physiology
  • Signal Transduction
  • Vascular Cell Adhesion Molecule-1 / physiology


  • Immunoglobulins
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1