To enhance clinical science and hasten the translation of research to practice so as to ultimately improve health, an increasing emphasis is being placed on transdisciplinary research. The purpose of this article is to describe the development of transdisciplinary clinical research in nursing, the current state of the science, potential threats to the discipline, and the promise of transdisciplinary research for nursing and for the health of the public. To successfully engage in transdisciplinary research, nurse scientists can use multiple strategies, including continuing to prepare researchers in rigorous pre-doctoral and postdoctoral training programs.