Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 268 (2), 314-24

Receptor Tyrosine Kinase AXL Is Induced by Chemotherapy Drugs and Overexpression of AXL Confers Drug Resistance in Acute Myeloid Leukemia

Affiliations

Receptor Tyrosine Kinase AXL Is Induced by Chemotherapy Drugs and Overexpression of AXL Confers Drug Resistance in Acute Myeloid Leukemia

Chih-Chen Hong et al. Cancer Lett.

Abstract

By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be induced by chemotherapy drugs in the acute myeloid leukemia U937 cells and this induction was dependent on the CCWGG methylation status of the AXL promoter. In U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induced AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways. The Gas6-AXL activation pathway of drug resistance was associated with increased expression of Bcl-2 and Twist. These results show that upregulation of AXL by chemotherapy might induce drug resistance in acute myeloid leukemia in the presence of Gas6 stimulation.

Similar articles

See all similar articles

Cited by 76 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

Feedback