Sansanmycins B and C, new components of sansanmycins

Yunying Xie; Hongzhang Xu; Shuyi Si; Chenghang Sun; Ruxian Chen

doi:10.1038/ja.2008.34

Sansanmycins B and C, new components of sansanmycins

J Antibiot (Tokyo). 2008 Apr;61(4):237-40. doi: 10.1038/ja.2008.34.

Authors

Yunying Xie¹, Hongzhang Xu, Shuyi Si, Chenghang Sun, Ruxian Chen

Affiliation

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, China.

PMID: 18503203
DOI: 10.1038/ja.2008.34

Abstract

Two new antibiotics, sansanmycins B and C, were isolated from Streptomyces sp. SS. Their structures were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Sansanmycins B and C exhibited inhibitory activity against our test strain of Pseudomonas aeruginosa with MIC values of 8.0 and 16 microg/ml, respectively. Sansanmycin B also exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant Mycobacterium tuberculosis, with the MIC values ranging from 8.0 to 20 microg/ml.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Oligopeptides / chemistry
Oligopeptides / isolation & purification*
Oligopeptides / pharmacology
Streptomyces / metabolism*
Uridine / analogs & derivatives*
Uridine / chemistry
Uridine / isolation & purification
Uridine / pharmacology

Substances

Anti-Bacterial Agents
Oligopeptides
sansanmycin B
Uridine