Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus

J Antibiot (Tokyo). 2008 Apr;61(4):245-9. doi: 10.1038/ja.2008.36.

Abstract

Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspergillus flavus / metabolism*
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Humans
  • Magnetic Resonance Spectroscopy
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Receptors, G-Protein-Coupled / metabolism
  • Spectrometry, Mass, Electrospray Ionization
  • Water Microbiology

Substances

  • GPR12 protein, human
  • Pyrones
  • Receptors, G-Protein-Coupled