Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition

Biochem Biophys Res Commun. 2008 Aug 8;372(4):509-12. doi: 10.1016/j.bbrc.2008.05.081. Epub 2008 May 27.


IL-12 is an important type 1 immune activation cytokine. It is known that macrophages and dendritic cells the major cell types producing this cytokine and that these cells may release both the biologically inactive form (IL-12p40) and active form (IL-12p70) of IL-12. In this review, the latest information regarding the regulatory mechanisms governing the production of IL-12p70 by these cells is evaluated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Dendritic Cells / immunology
  • Genetic Variation
  • Humans
  • Interleukin-12 / antagonists & inhibitors*
  • Interleukin-12 / genetics
  • Interleukin-12 / metabolism*
  • Macrophages / immunology
  • Mice


  • Interleukin-12