Abstract
Experiments were carried out on 14-day fetal mouse thymic stem cells which were treated with agents known to increase cellular cAMP levels for a period of 90 min at 37 degrees C. When compared to controls, a high proportion of treated stem cells were found to develop Thy-1 (theta) antigen as indicated by dye exclusion tests using anti-Thy-1 serum and complement.
MeSH terms
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Animals
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Bucladesine / pharmacology
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Cell Differentiation / drug effects
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Cyclic AMP / pharmacology*
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Cytotoxicity Tests, Immunologic
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Isoantigens
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Mice
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Mice, Inbred BALB C
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Prostaglandins / pharmacology*
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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Thymus Gland / embryology*
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Thymus Gland / immunology
Substances
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Isoantigens
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Prostaglandins
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Bucladesine
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Cyclic AMP