Anthelmintic acetogenin from Annona squamosa L. Seeds

Marta M C Souza; Claudia M L Bevilaqua; Selene M Morais; Cícero T C Costa; Ana R A Silva; Raimundo Braz-Filho

doi:10.1590/s0001-37652008000200005

Anthelmintic acetogenin from Annona squamosa L. Seeds

An Acad Bras Cienc. 2008 Jun;80(2):271-7. doi: 10.1590/s0001-37652008000200005.

Authors

Marta M C Souza¹, Claudia M L Bevilaqua, Selene M Morais, Cícero T C Costa, Ana R A Silva, Raimundo Braz-Filho

Affiliation

¹ Laboratório de Doenças Parasitárias, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.

PMID: 18506253
DOI: 10.1590/s0001-37652008000200005

Abstract

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetogenins / chemistry
Acetogenins / isolation & purification
Acetogenins / pharmacology*
Animals
Annona / chemistry*
Anthelmintics / chemistry
Anthelmintics / isolation & purification
Anthelmintics / pharmacology*
Haemonchus / drug effects*
Ovum / drug effects*
Parasitic Sensitivity Tests
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Seeds / chemistry
Spectrum Analysis

Substances

Acetogenins
Anthelmintics
Plant Extracts