Minimizing acquisition time of arterial spin labeling at 3T

Magn Reson Med. 2008 Jun;59(6):1467-71. doi: 10.1002/mrm.21633.


An improved arterial spin labeling (ASL) perfusion technique that combines pseudo-continuous labeling and a T2*-insensitive sequence (GRASE) with background suppression was used to acquire perfusion maps in normal volunteers and stroke patients. It is shown that perfusion measurements obtained in less than 1 min of scan time are reproducible, with a coefficient of variation of 7%. The perfusion maps generated from these data can be used to characterize the stroke lesion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Blood Flow Velocity
  • Cerebral Arteries / physiology*
  • Cerebrovascular Circulation / physiology*
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spin Labels
  • Stroke / physiopathology*


  • Spin Labels