Abstract
Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl.LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkalies / chemistry
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Combinatorial Chemistry Techniques*
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Indicators and Reagents
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Magnesium / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry*
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Pyrimidines / chemistry*
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Stereoisomerism
Substances
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Alkalies
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Indicators and Reagents
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Organometallic Compounds
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Pyrimidines
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TMPMgCl.LiCl
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Magnesium