Concomitant-acquired Long QT and Brugada syndromes associated with indapamide-induced hypokalemia and hyponatremia

Pacing Clin Electrophysiol. 2008 Jun;31(6):772-5. doi: 10.1111/j.1540-8159.2008.01085.x.


Electrolyte disturbances are known to cause acquired Long QT syndrome (LQTS) and Brugada syndrome. While a reduction in INa due to SCN5A mutation is implicated as the underlying mechanism in Brugada syndrome, hyponatremia, which can give rise to a reduced INa, has never been reported in literature as a cause or precipitating factor in this syndrome. We detailed a case in which concomitant-acquired LQTS and Brugada syndrome were associated with severe hypokalemia and hyponatremia following indapamide use for treatment of hypertension and highlighted the potential role of hyponatremia in the pathogenesis of the acquired form of Brugada syndrome.

Publication types

  • Case Reports

MeSH terms

  • Antihypertensive Agents / adverse effects
  • Brugada Syndrome / chemically induced*
  • Brugada Syndrome / diagnosis
  • Humans
  • Hypokalemia / chemically induced*
  • Hypokalemia / diagnosis
  • Hyponatremia / chemically induced*
  • Hyponatremia / diagnosis
  • Indapamide / adverse effects*
  • Long QT Syndrome / chemically induced*
  • Long QT Syndrome / diagnosis
  • Male
  • Middle Aged


  • Antihypertensive Agents
  • Indapamide