Multifunctional magnetic nanoparticles for targeted imaging and therapy

Adv Drug Deliv Rev. 2008 Aug 17;60(11):1241-51. doi: 10.1016/j.addr.2008.03.014. Epub 2008 Apr 10.

Abstract

Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / diagnosis
  • Biocompatible Materials / therapeutic use
  • Diagnostic Imaging / methods
  • Drug Delivery Systems / methods*
  • Ferric Compounds / chemistry
  • Humans
  • Magnetics*
  • Nanoparticles* / chemistry
  • Nanoparticles* / therapeutic use
  • Neoplasms / diagnosis

Substances

  • Biocompatible Materials
  • Ferric Compounds
  • ferric oxide