Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces

J Biomed Mater Res A. 2009 Aug;90(2):351-61. doi: 10.1002/jbm.a.32097.

Abstract

The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Alumina-blasted/acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 30-50 nm and IBAD II = 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry
  • Aluminum Oxide / chemistry*
  • Animals
  • Biocompatible Materials / chemistry*
  • Biomechanical Phenomena
  • Bone Substitutes
  • Ceramics / chemistry*
  • Dogs
  • Durapatite / chemistry
  • Fracture Healing
  • Male
  • Stress, Mechanical
  • Surface Properties
  • Titanium / chemistry*
  • Torque

Substances

  • Acids
  • Biocompatible Materials
  • Bone Substitutes
  • titanium alloy (TiAl6V4)
  • Durapatite
  • Titanium
  • Aluminum Oxide