Plant ARGONAUTES

Trends Plant Sci. 2008 Jul;13(7):350-8. doi: 10.1016/j.tplants.2008.04.007. Epub 2008 May 26.

Abstract

ARGONAUTE (AGO) proteins are integral players in all known small RNA-directed regulatory pathways. Eukaryotes produce numerous types of small RNAs, such as microRNAs (miRNA), small interfering RNAs (siRNA), PIWI-interacting RNAs (piRNAs), scanRNAs and 21U-RNAs, and these RNA species associate with different types of AGO family members, such as AGO, PIWI and group 3 proteins. Small RNA-guided AGO proteins regulate gene expression at various levels, including internal genomic DNA sequence elimination (in ciliates), translational repression (animals), and RNA cleavage (all eukaryotes), which in some cases is followed by DNA methylation and chromatin remodeling. The plant model species Arabidopsis contains ten AGO proteins belonging to three phylogenetic clades. This review covers our current knowledge of plant AGO functions during miRNA- and siRNA-mediated regulation of development and stress responses, siRNA-mediated antiviral immune response, and siRNA-mediated regulation of chromatin structure and transposons.

Publication types

  • Review

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / classification
  • Arabidopsis Proteins / genetics*
  • Arabidopsis Proteins / metabolism
  • Argonaute Proteins
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Mutation
  • Phylogeny
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • RNA, Small Interfering / genetics
  • RNA-Binding Proteins / classification
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism

Substances

  • AGO4 protein, Arabidopsis
  • Arabidopsis Proteins
  • Argonaute Proteins
  • MicroRNAs
  • Protein Isoforms
  • RNA, Small Interfering
  • RNA-Binding Proteins
  • ZIPPY protein, Arabidopsis