Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

Front Biosci. 2008 May 1;13:3215-38. doi: 10.2741/2922.

Abstract

Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adhesins, Bacterial / adverse effects*
  • Adhesins, Bacterial / biosynthesis
  • Adhesins, Bacterial / metabolism
  • Apoptosis
  • Bacterial Proteins / metabolism
  • Bacteroidaceae Infections / physiopathology*
  • Caspases / metabolism
  • Cysteine Endopeptidases / adverse effects*
  • Cysteine Endopeptidases / biosynthesis
  • Cysteine Endopeptidases / metabolism
  • DNA Repair
  • Genes, Bacterial
  • Gingipain Cysteine Endopeptidases
  • Glycosylation
  • Hemagglutinins / metabolism
  • Humans
  • Inflammation / microbiology
  • Inflammation / physiopathology
  • Oxidative Stress
  • Porphyromonas gingivalis / genetics
  • Porphyromonas gingivalis / pathogenicity
  • Porphyromonas gingivalis / physiology*
  • Reactive Oxygen Species / metabolism
  • Virulence

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • Gingipain Cysteine Endopeptidases
  • Hemagglutinins
  • Reactive Oxygen Species
  • Caspases
  • Cysteine Endopeptidases