The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine

Front Biosci. 2008 May 1;13:4144-74. doi: 10.2741/2998.

Abstract

The mouse secretory phospholipase A2 group IIA (sPLA2-IIA) gene Pla2g2a has been identified as a susceptibility gene for cancer of the small and large intestine. Interestingly, unlike most previously identified tumor susceptibility genes, Pla2g2a does not behave like a classical oncogene or tumor suppressor gene. Hence, identification of its biological functions in tumor development may shed new light on general mechanisms that modulate colon cancer risk. So far, sPLA2-IIA has been proposed to play a role in anti-bacterial defense, inflammation and eicosanoid generation, in clearance of apoptotic cells, and in the Wnt signaling pathway. More recently, comparison of RNA expression profiles of colon from Pla2g2a-transgenic to Pla2g2a-deficient mice confirmed and even extended sPLA2-IIA's diverse biological effects. In this review we aim to summarize current knowledge about the various links of sPLA2-IIA to cancer of the gastro-intestinal tract, and propose several models to illustrate its putative biological effects on tumor development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / physiopathology
  • Genetic Predisposition to Disease*
  • Group II Phospholipases A2 / genetics*
  • Group II Phospholipases A2 / metabolism
  • Homeostasis
  • Humans
  • Inflammation / genetics
  • Inflammation / physiopathology
  • Intestinal Neoplasms / enzymology
  • Intestinal Neoplasms / genetics*
  • Intestinal Neoplasms / pathology
  • Intestinal Neoplasms / physiopathology
  • Mice
  • Receptors, Notch / physiology
  • Signal Transduction
  • Wnt Proteins / physiology

Substances

  • Receptors, Notch
  • Wnt Proteins
  • Group II Phospholipases A2
  • PLA2G2A protein, human
  • Pla2g2a protein, mouse