Protein tyrosine phosphatases in the JAK/STAT pathway

Front Biosci. 2008 May 1;13:4925-32. doi: 10.2741/3051.

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Janus Kinase 1 / metabolism
  • Janus Kinases / metabolism*
  • Leukocyte Common Antigens / metabolism
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / metabolism
  • Protein Tyrosine Phosphatases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Receptors, Erythropoietin / physiology
  • Signal Transduction
  • Trans-Activators
  • src Homology Domains

Substances

  • Receptors, Erythropoietin
  • Trans-Activators
  • Janus Kinase 1
  • Janus Kinases
  • Protein-Serine-Threonine Kinases
  • Leukocyte Common Antigens
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases