Phytate reduces age-related cardiovascular calcification

Front Biosci. 2008 May 1;13:7115-22. doi: 10.2741/3214.


The aim of this research was to evaluate the effect of dietary phytate on cardiovascular calcification in rats during aging. Male Wistar rats (10 weeks old) were randomly assigned to four diet groups. The control group was fed with a balanced diet (UAR-A04) containing phytate. The AIN group was fed a purified diet (AIN-76A) with an undetectable level of phytate. The PHY group was fed with a purified diet (AIN-76A) enriched with phytate (phytin, as the calcium magnesium salt). The MOD group was fed with the AIN-76A diet (phytate undetectable) enriched with MgO, inositol and CaHPO4. At 76 weeks of age all rats were sacrificed, and the aortas, hearts, kidneys, livers and femurs were removed for chemical analysis. The most significant differences were found in the aorta calcium content. Phytate-treated rats (the control and PHY groups) had significantly lower levels of calcium in the aorta compared to nonphytate-treated rats (AIN and MOD groups). The present study demonstrated that dietary phytate treatment significantly reduced age-related aorta calcification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aging / drug effects
  • Aging / physiology*
  • Animal Feed
  • Animals
  • Aorta / drug effects
  • Aorta / pathology
  • Aortic Diseases / physiopathology
  • Aortic Diseases / prevention & control*
  • Calcinosis / prevention & control*
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / prevention & control*
  • Male
  • Phytic Acid / administration & dosage
  • Phytic Acid / therapeutic use*
  • Rats
  • Rats, Wistar


  • Phytic Acid