InteroPORC: automated inference of highly conserved protein interaction networks

Bioinformatics. 2008 Jul 15;24(14):1625-31. doi: 10.1093/bioinformatics/btn249. Epub 2008 May 28.


Motivation: Protein-protein interaction networks provide insights into the relationships between the proteins of an organism thereby contributing to a better understanding of cellular processes. Nevertheless, large-scale interaction networks are available for only a few model organisms. Thus, interologs are useful for a systematic transfer of protein interaction networks between organisms. However, no standard tool is available so far for that purpose.

Results: In this study, we present an automated prediction tool developed for all sequenced genomes available in Integr8. We also have developed a second method to predict protein-protein interactions in the widely used cyanobacterium Synechocystis. Using these methods, we have constructed a new network of 8783 inferred interactions for Synechocystis.

Availability: InteroPORC is open-source, downloadable and usable through a web interface at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Automation
  • Computational Biology / methods*
  • Computer Simulation
  • Cyanobacteria / genetics*
  • Cyanobacteria / metabolism
  • Genome, Bacterial
  • Internet
  • Models, Biological
  • Protein Interaction Mapping*
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Signal Processing, Computer-Assisted
  • Software
  • Synechocystis / genetics
  • Synechocystis / metabolism*
  • Systems Biology


  • Proteins