One-step multicomponent encapsulation by compound-fluidic electrospray

J Am Chem Soc. 2008 Jun 25;130(25):7800-1. doi: 10.1021/ja801803x. Epub 2008 May 30.


Fabrication of sophisticated or smart materials often needs controlled integrating multiple components into a single capsule. Most of conventional microencapsulation strategies merely envelop one content into a shell every time. We report a compound-fluidic electrospray method could one-step enclose multiple components into a single microcapsule without contact. The as-prepared microcapsules have multiple compartments inside, in each of which different content can be addressably loaded. This approach gives flexibility for generating diverse microcapsules that could one-step integrate different active components in microscopic domain free of contact, which may find potential applications in multicomponent drug delivery, microreactors and others.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Compounding / instrumentation*
  • Drug Compounding / methods*
  • Fluorescent Dyes / chemistry
  • Glycerol / chemistry
  • Microspheres
  • Particle Size
  • Polymers / chemistry
  • Titanium / chemistry


  • Fluorescent Dyes
  • Polymers
  • titanium dioxide
  • Titanium
  • Glycerol