Adaptive properties and heterogeneity of dopamine D(2) receptors - pharmacological implications

Brain Res Rev. 2008 Aug;58(2):374-8. doi: 10.1016/j.brainresrev.2007.09.007. Epub 2007 Oct 2.


In this review, we focus on the marked adaptability of dopamine D(2) receptors to varying agonist levels and we discuss the extent to which this phenomenon can account for the heterogeneity of these receptors in regard to function and pharmacological responsiveness. We emphasize the significance of a distinction between synaptic and extrasynaptic receptors in this context. For example, the application of this dichotomy appears to shed new light on the various subgroups of antipsychotic drugs and the mechanisms underlying their different profiles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / drug effects*
  • Adaptation, Physiological / physiology
  • Animals
  • Dopamine Agents / pharmacology*
  • Humans
  • Neuronal Plasticity / drug effects*
  • Receptors, Dopamine D2 / physiology*


  • Dopamine Agents
  • Receptors, Dopamine D2